TSC1

Across TCGA cell cohorts, TSC1 mutation is significantly associated with the RNA expression of many other genes, with 773 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSC1-associated genes across cancer lineages are MYF5, TAS2R7, and OR1L6. Each is linked with TSC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSC1-to-partner and partner-to-TSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF5 grouped by TSC1-low versus TSC1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC1→partner) and Y-score (partner→TSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYF5 →	+0.016	+5.000	<.001	.006	3	2
BONE	TAS2R7 →	+0.020	+5.169	<.001	.004	3	1
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
BONE	OR10G8 →	+0.020	+5.169	<.001	.004	3	1
PANCREAS	OR2T35 →	+0.020	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 773 associations by consensus.

MYF5 by TSC1 expression — PANCREAS

Explore this box plot interactively →