Across TCGA patient cohorts, TSBP1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSBP1-associated genes across cancer lineages are PRDX1, 4E-BP1, and Cyclin-B1. Each is linked with TSBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSBP1-to-partner and partner-to-TSBP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSBP1→partner) and Y-score (partner→TSBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PRDX1 →	+0.277	+2.115	.029	.018	3	3
UCEC	4E-BP1 →	+0.311	+3.489	.002	.002	3	2
UCEC	Cyclin-B1 →	+0.705	+3.584	.001	.002	3	2
UCEC	Di-Ras3 →	-0.154	-2.584	.006	.001	3	2
SKCM	p53 →	+0.282	+3.713	<.001	<.001	3	2
SKCM	14-3-3_epsilon →	+0.143	+2.132	.006	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

TSBP1 survival (RNA) · tumor vs normal (RNA) · all TSBP1 data types