Across TCGA pan-cancer cohorts, TSBP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TSBP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSBP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSBP1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, LUSC, and KICH are the cancer types where TSBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.235	<.001	12	view →
LUSC	All	All	+0.528	<.001	4	view →
KICH	All	All	−0.058	.003	2	view →
COAD	Female	II,III,IV	−0.021	.010	2	view →
THCA	Female	II,III,IV	+0.037	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TSBP1 RNA expression & survival · all TSBP1 data types