Across TCGA cell cohorts, TSBP1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSBP1-associated genes across cancer lineages are CCER1, MAGEB4, and STRA8. Each is linked with TSBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSBP1-to-partner and partner-to-TSBP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSBP1→partner) and Y-score (partner→TSBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCER1 →	+0.030	+5.643	<.001	.002	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MINAR2 →	+0.053	+4.467	<.001	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

TSBP1 survival (RNA) · tumor vs normal (RNA) · all TSBP1 data types