TRUB1

Across TCGA pan-cancer cohorts, TRUB1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRUB1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TRUB1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TRUB1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where TRUB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRUB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.456	<.001	9	view →
LUAD	Male	III,IV	+0.387	<.001	8	view →
CCRCC	Male	All	−0.148	<.001	8	view →
COAD	All	All	+0.097	.023	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TRUB1–LSCC

Open the LSCC breakdown →