TRPV3

Across TCGA pan-cancer cohorts, TRPV3 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TRPV3 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TRPV3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRPV3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, BLCA, and SKCM are the cancer types where TRPV3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.165	0.707	<.001	36	view →
BLCA	DFS	Median	III,IV	0.185	0.574	.017	9	view →
SKCM	DFS	Median	All	0.087	0.757	.002	9	view →
CESC	DFS	Median	II,III,IV	0.146	0.705	.010	6	view →
PRAD	DFS	Median	All	0.085	0.774	.001	6	view →
LUSC	DFS	Median	All	0.233	0.711	.027	6	view →
UCEC	DFS	Median	All	0.947	0.828	.035	4	view →
STAD	OS	Median	III,IV	0.228	0.640	.035	3	view →
LUAD	OS	Median	II,III,IV	0.255	0.543	.048	3	view →
COAD	OS	Median	II,III,IV	0.176	0.655	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TRPV3–ESCA (OS)

Open the ESCA breakdown →