TRPV3

Across TCGA pan-cancer cohorts, TRPV3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TRPV3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRPV3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRPV3 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where TRPV3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRPV3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.449	<.001	12	view →
COAD	Female	II,III,IV	−1.363	<.001	10	view →
THCA	All	All	+0.286	<.001	9	view →
LUAD	Male	III,IV	+0.455	<.001	8	view →
LUSC	Male	II,III,IV	+1.156	<.001	7	view →
READ	All	All	−1.132	.002	5	view →
PAAD	All	All	+0.822	.012	4	view →
KIRP	All	III,IV	+0.343	.020	4	view →
KICH	Female	II,III,IV	−0.140	<.001	3	view →
KIRC	All	All	+0.137	.002	3	view →
CHOL	All	All	+0.757	.009	2	view →
PRAD	All	All	−0.134	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TRPV3–HNSC

Open the HNSC breakdown →