TRPV3

Across TCGA patient cohorts, TRPV3 mutation is significantly associated with the RNA expression of many other genes, with 3,764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPV3-associated genes across cancer lineages are SDHB, PPP1R8, and FAM98A. Each is linked with TRPV3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPV3-to-partner and partner-to-TRPV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDHB grouped by TRPV3-low versus TRPV3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV3→partner) and Y-score (partner→TRPV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SDHB →	+0.615	+3.353	.001	.005	3	3
SKCM	PPP1R8 →	+0.531	+3.341	.005	.005	3	3
SKCM	FAM98A →	+0.564	+3.341	.007	.005	3	3
READ	GNAT2 →	+0.043	+4.462	<.001	.001	3	3
LIHC	RNU2-24P →	+0.544	+4.451	<.001	.006	3	3
UCEC	MCM5 →	+0.563	+2.523	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,764 associations by consensus.

SDHB by TRPV3 expression — SKCM

Explore this box plot interactively →