TRPS1

Across TCGA patient cohorts, TRPS1 mutation is significantly associated with the RNA expression of many other genes, with 5,993 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPS1-associated genes across cancer lineages are RPP25, GPI, and CDC20. Each is linked with TRPS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPS1-to-partner and partner-to-TRPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPP25 grouped by TRPS1-low versus TRPS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPS1→partner) and Y-score (partner→TRPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPP25 →	+0.664	+1.616	.006	.005	3	5
UCEC	GPI →	+0.289	+1.425	.006	<.001	3	5
SKCM	CDC20 →	+0.545	+1.784	.006	.007	3	5
SKCM	FBXO5 →	+0.586	+2.247	<.001	.005	3	4
UCEC	SKA1 →	+0.598	+1.702	<.001	<.001	3	4
SKCM	POC1A →	+0.567	+2.616	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,993 associations by consensus.

RPP25 by TRPS1 expression — SKCM

Explore this box plot interactively →