TRPM7

Across TCGA cell cohorts, TRPM7 mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM7-associated genes across cancer lineages are F9, UTF1, and MBD3L3. Each is linked with TRPM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPM7-to-partner and partner-to-TRPM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by TRPM7-low versus TRPM7-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM7→partner) and Y-score (partner→TRPM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	F9 →	+0.042	+5.321	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.226	+5.357	<.001	.003	3	2
BLOOD_Leukemia	MBD3L3 →	+0.018	+5.289	.008	<.001	3	2
URINARY_TRACT	PRAMEF9 →	+0.013	+5.087	<.001	.004	3	1
SOFT_TISSUE	ZAN →	+0.004	+4.369	<.001	.008	3	1
SOFT_TISSUE	IL27 →	+0.029	+4.882	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

F9 by TRPM7 expression — CNS

Explore this box plot interactively →