TRPM5

Across TCGA patient cohorts, TRPM5 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM5-associated genes across cancer lineages are PCNA, Annexin-1, and Shc_pY317. Each is linked with TRPM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPM5-to-partner and partner-to-TRPM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TRPM5-low versus TRPM5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM5→partner) and Y-score (partner→TRPM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.264	+2.700	<.001	.005	3	2
UCEC	Annexin-1 →	+0.648	+2.999	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.105	-1.392	.035	.019	3	2
UCEC	Cyclin-B1 →	+0.484	+1.652	.008	.006	3	2
UCEC	ERK2 →	+0.192	+2.584	.002	.001	3	1
UCEC	MEK1 →	+0.265	+1.807	.028	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PCNA by TRPM5 expression — SKCM

Explore this box plot interactively →