TRPM5

Across TCGA cell cohorts, TRPM5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,473 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM5-associated GO terms across cancer lineages are Cortisol metabolic process, Corticosteroid hormone secretion, and Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Each is linked with TRPM5 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPM5-to-partner and partner-to-TRPM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cortisol metabolic process grouped by TRPM5-low versus TRPM5-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM5→partner) and Y-score (partner→TRPM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cortisol metabolic process →	+0.769	+0.673	.003	<.001	3	5
LARGE_INTESTINE	Corticosteroid hormone secretion →	+1.191	+0.586	<.001	<.001	3	5
STOMACH	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.097	+0.375	<.001	.004	3	5
LARGE_INTESTINE	Negative regulation of blood circulation →	+0.123	+0.499	.002	.005	3	4
LARGE_INTESTINE	Positive regulation of blood vessel branching →	+0.100	+0.563	<.001	.002	3	4
LARGE_INTESTINE	Positive regulation of ceramide biosynthetic process →	+0.111	+0.654	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,473 associations by consensus.

Cortisol metabolic process by TRPM5 expression — LARGE_INTESTINE

Explore this box plot interactively →