TRPM5

Across TCGA cell cohorts, TRPM5 mutation is significantly associated with the RNA expression of many other genes, with 618 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM5-associated genes across cancer lineages are PPIAL4D, C12orf40, and NOX3. Each is linked with TRPM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPM5-to-partner and partner-to-TRPM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4D grouped by TRPM5-low versus TRPM5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM5→partner) and Y-score (partner→TRPM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPIAL4D →	+0.112	+3.747	.001	.008	3	2
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	2
OESOPHAGUS	NOX3 →	+0.022	+4.392	<.001	.003	3	1
BLOOD_Lymphoma	CFC1 →	+0.534	+4.452	<.001	.001	3	1
BLOOD_Lymphoma	GPR26 →	+0.016	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	OR7D4 →	+0.031	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 618 associations by consensus.

PPIAL4D by TRPM5 expression — SKIN

Explore this box plot interactively →