TRPM4

Across TCGA pan-cancer cohorts, TRPM4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TRPM4 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRPM4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TRPM4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where TRPM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.405	.030	8	view →
GBM	DFS	Quartile	All	0.248	0.615	.017	4	view →
CCRCC	DFS	Tertile	IV	0.303	1.000	.036	4	view →
PDAC	DFS	Median	All	0.715	0.873	.004	3	view →
LSCC	DFS	Tertile	II,III,IV	0.399	1.000	.040	3	view →
LUAD	DFS	Tertile	All	0.907	1.000	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TRPM4–HNSC (DFS)

Open the HNSC breakdown →