TRPM4

Across TCGA pan-cancer cohorts, TRPM4 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TRPM4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRPM4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TRPM4 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and PDAC are the cancer types where TRPM4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRPM4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.785	<.001	12	view →
CCRCC	Male	III,IV	−0.599	<.001	12	view →
PDAC	Female	II,III,IV	+0.866	<.001	11	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TRPM4–COAD

Open the COAD breakdown →