TRPM3

Across TCGA pan-cancer cohorts, TRPM3 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TRPM3 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRPM3 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TRPM3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, THYM, and LUAD are the cancer types where TRPM3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.900	0.427	.008	28	view →
THYM	OS	Median	All	0.039	0.928	<.001	24	view →
LUAD	OS	Median	II,III,IV	0.273	0.688	<.001	18	view →
LIHC	OS	Median	All	0.215	0.712	<.001	14	view →
SARC	DFS	Median	All	0.170	0.614	.004	6	view →
BLCA	OS	Median	II,III,IV	0.827	0.418	.025	4	view →
SKCM	DFS	Median	IV	1.000	0.241	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TRPM3–UCEC (DFS)

Open the UCEC breakdown →