TRPM2-AS

Across TCGA pan-cancer cohorts, TRPM2-AS RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TRPM2-AS data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher TRPM2-AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRPM2-AS expression acts as an unfavorable survival marker, although some lineages such as UCEC and PAAD show a favorable association.

UVM, LGG, and UCEC are the cancer types where TRPM2-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.348	0.680	.005	73	view →
LGG	DFS	Median	All	0.671	0.795	<.001	40	view →
UCEC	OS	Quartile	All	0.809	0.631	<.001	38	view →
PAAD	DFS	Tertile	II,III,IV	0.492	0.333	.007	36	view →
THCA	DFS	Quartile	All	0.930	0.709	<.001	34	view →
BLCA	DFS	Tertile	III,IV	0.351	0.234	.010	25	view →
KIRP	OS	Tertile	II,III,IV	0.230	0.814	.021	25	view →
OV	OS	Tertile	III,IV	0.326	0.441	.004	22	view →
KIRC	DFS	Tertile	II,III,IV	0.474	0.651	.005	21	view →
COAD	OS	Median	IV	0.455	0.832	.001	20	view →
LUSC	OS	Tertile	II,III,IV	0.528	0.348	.009	20	view →
SKCM	DFS	Median	II,III,IV	0.575	0.783	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TRPM2-AS–UVM (DFS)

Open the UVM breakdown →