TRPC7-AS2

Across TCGA pan-cancer cohorts, TRPC7-AS2 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TRPC7-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRPC7-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRPC7-AS2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where TRPC7-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRPC7-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.038	.003	8	view →
KIRC	Male	All	−0.238	<.001	7	view →
KICH	All	II,III,IV	−0.218	<.001	7	view →
KIRP	All	All	−0.233	.001	6	view →
LUSC	All	All	+0.018	.007	3	view →
STAD	All	III,IV	+0.085	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TRPC7-AS2–HNSC

Open the HNSC breakdown →