TRPC5

Across TCGA patient cohorts, TRPC5 mutation is significantly associated with the RNA expression of many other genes, with 8,564 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPC5-associated genes across cancer lineages are GSKIP, OIP5, and DLGAP5. Each is linked with TRPC5 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPC5-to-partner and partner-to-TRPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSKIP grouped by TRPC5-low versus TRPC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC5→partner) and Y-score (partner→TRPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSKIP →	+0.496	+1.887	<.001	<.001	3	5
UCEC	OIP5 →	+0.884	+2.536	<.001	<.001	3	5
UCEC	DLGAP5 →	+0.753	+1.721	<.001	<.001	3	5
UCEC	NUSAP1 →	+0.820	+2.514	<.001	<.001	3	5
UCEC	PDSS1 →	+0.374	+1.684	<.001	.002	3	5
UCEC	DLAT →	+0.627	+2.078	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,564 associations by consensus.

GSKIP by TRPC5 expression — UCEC

Explore this box plot interactively →