TRPC5

Across TCGA pan-cancer cohorts, TRPC5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TRPC5 data layer compared with 12 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher TRPC5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRPC5 expression acts as an unfavorable survival marker, although some lineages such as THCA and ESCA show a favorable association.

THCA, ACC, and CHOL are the cancer types where TRPC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.965	0.854	<.001	37	view →
ACC	OS	Tertile	III,IV	0.594	0.816	.036	27	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	18	view →
ESCA	OS	Tertile	III,IV	0.657	0.434	.019	18	view →
LUAD	OS	Quartile	IV	0.427	0.798	.012	18	view →
KICH	OS	Quartile	III,IV	0.178	0.803	<.001	16	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	16	view →
UVM	OS	Tertile	All	0.399	0.774	.020	12	view →
STAD	DFS	Quartile	IV	0.112	0.647	.011	12	view →
PAAD	OS	Tertile	All	0.693	0.468	.026	12	view →
PRAD	DFS	Tertile	All	0.971	0.923	.019	12	view →
KIRC	DFS	Tertile	IV	0.679	0.238	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TRPC5–THCA (DFS)

Open the THCA breakdown →