TRPC5

Across TCGA patient cohorts, TRPC5 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPC5-associated genes across cancer lineages are HER2, P-Cadherin, and eEF2. Each is linked with TRPC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPC5-to-partner and partner-to-TRPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2 grouped by TRPC5-low versus TRPC5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC5→partner) and Y-score (partner→TRPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	HER2 →	+0.434	+2.468	.007	.011	3	3
LUAD	P-Cadherin →	+0.194	+1.601	.026	.043	3	3
UCEC	eEF2 →	+0.271	+1.999	.009	.008	3	3
UCEC	GATA6 →	-0.136	-1.425	.002	.005	3	3
UCEC	Chk2_pT68 →	-0.144	-1.990	.007	.002	3	3
UCEC	C-Raf →	+0.176	+1.874	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

HER2 by TRPC5 expression — LUSC

Explore this box plot interactively →