TRPC5

Across TCGA cell cohorts, TRPC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 846 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRPC5-associated GO terms across cancer lineages are Negative regulation of mRNA processing, Negative regulation of proteasomal protein catabolic process, and mRNA transport. Each is linked with TRPC5 in more than 6 cancer types. Because this analysis shows association rather than direction, both TRPC5-to-partner and partner-to-TRPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA processing grouped by TRPC5-low versus TRPC5-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC5→partner) and Y-score (partner→TRPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of mRNA processing →	+0.079	+0.271	.001	.002	2	7
BLOOD_Leukemia	Negative regulation of proteasomal protein catabolic process →	+0.060	+0.007	<.001	.004	3	5
BLOOD_Leukemia	mRNA transport →	+0.046	+0.007	<.001	<.001	3	5
OESOPHAGUS	Internal protein amino acid acetylation →	+0.112	+0.005	.005	<.001	3	4
BLOOD_Leukemia	Endosomal transport →	+0.022	+0.008	<.001	<.001	3	4
BLOOD_Leukemia	Regulatory ncRNA-mediated gene silencing →	+0.032	+0.007	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 846 associations by consensus.

Negative regulation of mRNA processing by TRPC5 expression — LUNG_SCLC

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