TRPC5

Across TCGA cell cohorts, TRPC5 mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPC5-associated genes across cancer lineages are OR13C5, PF4V1, and HSD11B1. Each is linked with TRPC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC5-to-partner and partner-to-TRPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C5 grouped by TRPC5-low versus TRPC5-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC5→partner) and Y-score (partner→TRPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR13C5 →	+0.019	+3.727	<.001	.002	3	2
LUNG_SCLC	PF4V1 →	+0.713	+2.869	.004	.008	3	1
LUNG_SCLC	HSD11B1 →	+0.554	+2.906	.003	.007	3	1
LUNG_SCLC	RBMY1E →	+0.646	+3.099	<.001	.003	3	1
URINARY_TRACT	IL17F →	+0.042	+4.087	<.001	.009	3	1
URINARY_TRACT	IDI2 →	+0.025	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

OR13C5 by TRPC5 expression — BREAST

Explore this box plot interactively →