TRPC4AP

Across TCGA pan-cancer cohorts, TRPC4AP Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRPC4AP data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TRPC4AP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRPC4AP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, COAD, and STAD are the cancer types where TRPC4AP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.067	0.874	<.001	36	view →
COAD	DFS	Median	All	0.234	0.694	<.001	12	view →
STAD	OS	Median	III,IV	0.003	0.630	<.001	6	view →
SKCM	OS	Median	All	0.193	0.781	<.001	6	view →
UCEC	DFS	Median	All	0.954	0.828	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRPC4AP–KIRC (OS)

Open the KIRC breakdown →