TRPC3

Across TCGA patient cohorts, TRPC3 mutation is significantly associated with the RNA expression of many other genes, with 6,619 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPC3-associated genes across cancer lineages are MNAT1, KIAA0586, and VRK1. Each is linked with TRPC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPC3-to-partner and partner-to-TRPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MNAT1 grouped by TRPC3-low versus TRPC3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC3→partner) and Y-score (partner→TRPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MNAT1 →	+0.444	+3.183	.001	.009	3	5
UCEC	KIAA0586 →	+0.327	+1.384	<.001	<.001	3	4
UCEC	VRK1 →	+0.429	+1.901	.001	<.001	3	4
UCEC	PSMC1 →	+0.406	+2.223	<.001	<.001	3	4
LUSC	PPP4R3A →	+0.503	+2.744	<.001	.003	3	4
UCEC	RBBP8 →	+0.708	+1.509	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,619 associations by consensus.

MNAT1 by TRPC3 expression — COAD

Explore this box plot interactively →