TRPC3

Across TCGA cell cohorts, TRPC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,156 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TRPC3-associated GO terms across cancer lineages are Regulation of G1/S transition of mitotic cell cycle, Ionotropic glutamate receptor signaling pathway, and Chromosome segregation. Each is linked with TRPC3 in more than 7 cancer types. Because this analysis shows association rather than direction, both TRPC3-to-partner and partner-to-TRPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of G1/S transition of mitotic cell cycle grouped by TRPC3-low versus TRPC3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC3→partner) and Y-score (partner→TRPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of G1/S transition of mitotic cell cycle →	+0.054	+0.819	<.001	<.001	3	8
OVARY	Ionotropic glutamate receptor signaling pathway →	-0.112	-0.143	<.001	.001	3	8
BLOOD_Leukemia	Chromosome segregation →	+0.041	+0.246	<.001	.008	3	8
BLOOD_Lymphoma	Epicardium-derived cardiac fibroblast cell differentiation →	-0.283	-0.560	<.001	<.001	3	7
BLOOD_Lymphoma	Epicardium-derived cardiac fibroblast cell development →	-0.283	-0.560	<.001	<.001	3	7
OVARY	Ligand-gated ion channel signaling pathway →	-0.107	-0.140	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,156 associations by consensus.

Regulation of G1/S transition of mitotic cell cycle by TRPC3 expression — CNS

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