TRPC3

Across TCGA cell cohorts, TRPC3 mutation is significantly associated with the mutation status of many other genes, with 4,774 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPC3-associated genes across cancer lineages are PPP1R13B, KMT2A, and ATP13A1. Each is linked with TRPC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPC3-to-partner and partner-to-TRPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R13B grouped by TRPC3-low versus TRPC3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC3→partner) and Y-score (partner→TRPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP1R13B →	+4.662	+3.963	<.001	<.001	1	5
BLOOD_Leukemia	KMT2A →	+2.662	+5.044	<.001	<.001	1	5
BLOOD_Leukemia	ATP13A1 →	+3.177	+3.531	<.001	<.001	1	5
LUNG_NSCLC_LUAD	FTMT →	+3.000	+3.662	.007	.007	1	5
STOMACH	XAB2 →	+4.807	+4.807	.008	.008	1	5
BLOOD_Leukemia	TEP1 →	+2.399	+2.962	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,774 associations by consensus.

PPP1R13B by TRPC3 expression — BLOOD_Leukemia

Explore this box plot interactively →