TRPC1

Across TCGA cell cohorts, TRPC1 mutation is significantly associated with the RNA expression of many other genes, with 208 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPC1-associated genes across cancer lineages are MAGEB5, ADGRG4, and DEFA1. Each is linked with TRPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC1-to-partner and partner-to-TRPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by TRPC1-low versus TRPC1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC1→partner) and Y-score (partner→TRPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BREAST	ADGRG4 →	+0.011	+4.421	.001	.004	3	1
BREAST	DEFA1 →	+0.371	+4.199	<.001	.007	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.053	+6.247	<.001	<.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.473	+3.451	.005	.002	3	1
LARGE_INTESTINE	HMGXB4 →	+0.550	+3.169	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 208 associations by consensus.

MAGEB5 by TRPC1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →