TRMU

Across TCGA patient cohorts, TRMU mutation is significantly associated with the RNA expression of many other genes, with 250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMU-associated genes across cancer lineages are ACTR3BP4, RPL39P25, and RPL5P26. Each is linked with TRMU in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMU-to-partner and partner-to-TRMU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTR3BP4 grouped by TRMU-low versus TRMU-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMU→partner) and Y-score (partner→TRMU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACTR3BP4 →	+0.056	+4.533	<.001	<.001	3	2
HNSC	RPL39P25 →	+0.253	+2.840	<.001	.009	3	2
HNSC	RPL5P26 →	+0.053	+3.272	.005	.002	3	2
COAD	TRAJ57 →	+0.738	+3.957	<.001	.003	3	2
COAD	RN7SKP65 →	+0.152	+4.251	<.001	.008	3	2
SKCM	RPS29P9 →	+0.269	+3.855	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 250 associations by consensus.

ACTR3BP4 by TRMU expression — SKCM

Explore this box plot interactively →