TRMU

Across TCGA pan-cancer cohorts, TRMU RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TRMU’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRMU RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRMU is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

HNSC, BLCA, and KIRC are the cancer types where TRMU tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRMU RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.072	<.001	12	view →
BLCA	Male	III,IV	+1.332	<.001	11	view →
KIRC	Female	All	+0.408	<.001	11	view →
COAD	Female	All	+1.148	<.001	10	view →
LIHC	Female	II,III,IV	+1.177	<.001	9	view →
STAD	All	II,III,IV	+1.101	<.001	8	view →
LUSC	Male	II,III,IV	+0.978	<.001	8	view →
LUAD	Female	All	+0.615	<.001	8	view →
UCEC	All	III,IV	+1.223	<.001	6	view →
ESCA	Male	All	+1.008	<.001	4	view →
BRCA	All	All	+0.239	.002	4	view →
CHOL	Male	All	+2.251	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TRMU–HNSC

Open the HNSC breakdown →