TRMU

Across TCGA patient cohorts, TRMU mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMU-associated genes across cancer lineages are Basophils, CD8+ Tem, and NK cells. Each is linked with TRMU in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMU-to-partner and partner-to-TRMU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Basophils grouped by TRMU-low versus TRMU-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMU→partner) and Y-score (partner→TRMU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Basophils →	+0.224	+2.830	.033	.036	2	2
ESCA	CD8+ Tem →	+0.018	+5.285	<.001	.049	3	1
ESCA	NK cells →	+0.002	+5.709	.002	.037	3	1
UCEC	Endothelial cells →	-0.050	-3.127	.017	.020	1	1
UCEC	lymphatic Endothelial cells →	-0.028	-3.116	.033	.020	1	1
UCEC	Melanocytes →	-0.014	-3.116	.014	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Basophils by TRMU expression — HNSC

Explore this box plot interactively →