TRMU

Across TCGA cell cohorts, TRMU mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRMU-associated genes across cancer lineages are LGI1, C20orf85, and FAM71B. Each is linked with TRMU in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMU-to-partner and partner-to-TRMU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by TRMU-low versus TRMU-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMU→partner) and Y-score (partner→TRMU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.023	+4.969	<.001	.003	3	1
BLOOD_Leukemia	FAM71B →	+0.016	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TMPRSS7 →	+0.075	+4.276	<.001	.007	3	1
BLOOD_Leukemia	TPRX1 →	+0.021	+5.060	<.001	.001	3	1
BLOOD_Leukemia	PRR30 →	+0.019	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

LGI1 by TRMU expression — BLOOD_Leukemia

Explore this box plot interactively →