TRMT2A

Across TCGA patient cohorts, TRMT2A mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT2A-associated genes across cancer lineages are A-Raf_pS299, Gab2, and Notch1. Each is linked with TRMT2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT2A-to-partner and partner-to-TRMT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TRMT2A-low versus TRMT2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT2A→partner) and Y-score (partner→TRMT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.179	-3.321	<.001	.010	3	1
UCEC	Gab2 →	+0.404	+2.000	.011	.032	3	1
UCEC	Notch1 →	+0.155	+2.000	.014	.032	3	1
UCEC	p62 Lck ligand →	+0.388	+2.331	.008	.019	3	1
UCEC	AMPK_pT172 →	+0.436	+2.013	.018	.018	3	1
UCEC	Annexin-1 →	+0.570	+3.019	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

A-Raf_pS299 by TRMT2A expression — UCEC

Explore this box plot interactively →