TRMT2A

Across TCGA pan-cancer cohorts, TRMT2A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TRMT2A data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TRMT2A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRMT2A expression acts as an unfavorable survival marker, although some lineages such as ESCA and SCLC show a favorable association.

UVM, ACC, and KICH are the cancer types where TRMT2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.464	0.962	<.001	124	view →
ACC	DFS	Median	All	0.218	0.679	<.001	113	view →
KICH	DFS	Median	III,IV	0.289	0.901	.001	68	view →
LIHC	OS	Median	All	0.707	0.839	<.001	60	view →
KIRC	DFS	Tertile	II,III,IV	0.422	0.612	.007	44	view →
COAD	DFS	Quartile	II,III,IV	0.368	0.776	.001	42	view →
ESCA	DFS	Tertile	All	0.886	0.183	.002	29	view →
SCLC	DFS	Median	III,IV	0.503	0.246	.015	22	view →
LUSC	DFS	Quartile	III,IV	0.315	0.722	.001	20	view →
DLBC	OS	Median	All	1.000	0.820	.014	12	view →
LAML	DFS	Tertile	All	0.342	0.639	.012	12	view →
READ	DFS	Tertile	All	0.922	0.674	.034	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TRMT2A–UVM (OS)

Open the UVM breakdown →