TRMT2A

Across TCGA cell cohorts, TRMT2A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TRMT2A-associated genes across cancer lineages are MMD2, GUCA2A, and PRSS54. Each is linked with TRMT2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT2A-to-partner and partner-to-TRMT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMD2 grouped by TRMT2A-low versus TRMT2A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT2A→partner) and Y-score (partner→TRMT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MMD2 →	+0.003	+4.569	<.001	.003	3	1
BLOOD_Leukemia	GUCA2A →	+0.018	+3.969	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRSS54 →	+0.047	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	SMIM9 →	+0.020	+3.734	.003	.006	3	1
LUNG_NSCLC_LUAD	GYPB →	+0.125	+3.544	<.001	.009	3	1
LARGE_INTESTINE	CPLX4 →	+0.024	+4.392	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MMD2 by TRMT2A expression — BLOOD_Leukemia

Explore this box plot interactively →