TRMT10C

Across TCGA patient cohorts, TRMT10C mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT10C-associated genes across cancer lineages are 14-3-3_beta, FASN, and FoxM1. Each is linked with TRMT10C in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT10C-to-partner and partner-to-TRMT10C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TRMT10C-low versus TRMT10C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT10C→partner) and Y-score (partner→TRMT10C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.098	-3.143	.021	.018	3	1
UCEC	FASN →	+0.394	+1.700	.018	.044	3	1
UCEC	FoxM1 →	+0.232	+2.222	.034	.011	3	1
UCEC	Heregulin →	-0.108	-2.986	.039	.035	3	1
UCEC	ACVRL1 →	-0.119	-2.565	.039	.010	3	1
UCEC	LKB1 →	-0.092	-3.000	.042	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

14-3-3_beta by TRMT10C expression — UCEC

Explore this box plot interactively →