TRMT10C

Across TCGA pan-cancer cohorts, TRMT10C RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TRMT10C data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TRMT10C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRMT10C expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

LIHC, READ, and KIRC are the cancer types where TRMT10C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.702	0.844	<.001	80	view →
READ	OS	Median	II,III,IV	0.887	0.306	.001	50	view →
KIRC	OS	Median	All	0.697	0.550	.001	46	view →
LUAD	DFS	Tertile	II,III,IV	0.423	0.717	.004	33	view →
ACC	DFS	Median	All	0.256	0.664	<.001	30	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	24	view →
UCEC	DFS	Median	All	0.785	0.883	<.001	20	view →
KICH	DFS	Quartile	II,III,IV	0.649	1.000	.018	19	view →
HNSC	DFS	Quartile	II,III,IV	0.502	0.681	.005	18	view →
MESO	OS	Median	II,III,IV	0.507	0.287	.003	11	view →
LGG	OS	Median	All	0.856	0.960	.003	5	view →
UVM	DFS	Tertile	III,IV	0.275	0.780	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TRMT10C–LIHC (OS)

Open the LIHC breakdown →