TRMT10C

Across TCGA cell cohorts, TRMT10C mutation is significantly associated with the mutation status of many other genes, with 3,302 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRMT10C-associated genes across cancer lineages are ATP1A4, MSH4, and HELB. Each is linked with TRMT10C in more than 2 cancer types. Because this analysis shows association rather than direction, both TRMT10C-to-partner and partner-to-TRMT10C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP1A4 grouped by TRMT10C-low versus TRMT10C-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT10C→partner) and Y-score (partner→TRMT10C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ATP1A4 →	+4.977	+4.415	.007	.007	1	3
OVARY	MSH4 →	+4.977	+4.415	.007	.007	1	3
OVARY	HELB →	+5.562	+5.562	<.001	<.001	1	3
LARGE_INTESTINE	MSH2 →	+2.974	+4.643	<.001	<.001	1	2
LARGE_INTESTINE	HOOK2 →	+3.874	+4.215	<.001	<.001	1	2
LARGE_INTESTINE	PTGS1 →	+1.974	+3.801	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,302 associations by consensus.

ATP1A4 by TRMT10C expression — OVARY

Explore this box plot interactively →