TRMT10B

Across TCGA patient cohorts, TRMT10B mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT10B-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FASN. Each is linked with TRMT10B in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT10B-to-partner and partner-to-TRMT10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TRMT10B-low versus TRMT10B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT10B→partner) and Y-score (partner→TRMT10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.238	-1.502	.009	.030	3	2
UCEC	eIF4E →	+0.175	+3.183	.024	.009	3	2
UCEC	FASN →	+0.358	+2.247	.013	.001	3	2
UCEC	MEK1 →	+0.367	+3.584	.006	.002	3	2
UCEC	mTOR_pS2448 →	-0.141	-2.446	.010	.018	3	2
UCEC	Notch1 →	+0.191	+3.472	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

EGFR_pY1068 by TRMT10B expression — UCEC

Explore this box plot interactively →