TRMT10B

Across TCGA pan-cancer cohorts, TRMT10B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated TRMT10B data layer compared with 3 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TRMT10B RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRMT10B expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

BRCA, PAAD, and ACC are the cancer types where TRMT10B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Quartile	All	0.956	0.871	<.001	48	view →
PAAD	DFS	Quartile	All	0.609	0.193	.003	39	view →
ACC	OS	Median	All	0.468	0.751	<.001	38	view →
BLCA	DFS	Quartile	All	0.494	0.277	.017	24	view →
THYM	DFS	Median	II,III,IV	0.946	0.493	.004	24	view →
MESO	DFS	Median	All	0.213	0.631	.001	21	view →
LIHC	OS	Tertile	All	0.706	0.847	.003	19	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
OV	DFS	Median	IV	0.565	0.352	.019	18	view →
SCLC	DFS	Median	II,III,IV	0.500	0.173	.004	18	view →
SARC	DFS	Quartile	All	0.536	0.365	.011	13	view →
UCS	OS	Tertile	III,IV	0.582	0.199	.035	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

TRMT10B–BRCA (OS)

Open the BRCA breakdown →