TRMO

Across TCGA patient cohorts, TRMO mutation is significantly associated with the RNA expression of many other genes, with 2,971 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMO-associated genes across cancer lineages are RN7SKP151, METTL7AP1, and TMEM225. Each is linked with TRMO in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMO-to-partner and partner-to-TRMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP151 grouped by TRMO-low versus TRMO-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMO→partner) and Y-score (partner→TRMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP151 →	+0.117	+3.628	<.001	.006	3	2
LUSC	METTL7AP1 →	+0.162	+4.993	<.001	.002	3	2
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	1
READ	RNU6-710P →	+0.429	+5.421	<.001	.005	3	1
READ	LINC01034 →	+0.258	+5.421	<.001	.005	3	1
READ	DPY19L2P5 →	+0.165	+5.925	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,971 associations by consensus.

RN7SKP151 by TRMO expression — BLCA

Explore this box plot interactively →