TRMO

Across TCGA patient cohorts, TRMO mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMO-associated genes across cancer lineages are INPP4B, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with TRMO in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMO-to-partner and partner-to-TRMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by TRMO-low versus TRMO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMO→partner) and Y-score (partner→TRMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.286	-2.321	.021	.033	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.394	-1.664	.022	.023	3	2
UCEC	PDCD4 →	-0.468	-1.874	.009	.049	3	2
UCEC	Rab25 →	-0.368	-2.459	.003	.018	3	2
UCEC	EGFR_pY1068 →	-0.282	-2.087	.003	.005	3	1
UCEC	EGFR →	-0.158	-1.678	.009	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

INPP4B by TRMO expression — UCEC

Explore this box plot interactively →