TRIP6

Across TCGA patient cohorts, TRIP6 mutation is significantly associated with the RNA expression of many other genes, with 565 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIP6-associated genes across cancer lineages are SNORD31B, HSPE1P22, and HMGB3P3. Each is linked with TRIP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIP6-to-partner and partner-to-TRIP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD31B grouped by TRIP6-low versus TRIP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP6→partner) and Y-score (partner→TRIP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD31B →	+0.298	+3.997	<.001	.001	3	3
UCEC	HSPE1P22 →	+0.147	+2.677	.008	.007	3	3
SKCM	HMGB3P3 →	+0.159	+5.292	<.001	.006	3	2
UCEC	KIR3DL1 →	+0.285	+3.910	<.001	.001	3	2
UCEC	KIR3DL2 →	+0.160	+2.728	.007	.009	3	2
UCEC	TRDV3 →	+0.383	+2.761	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 565 associations by consensus.

SNORD31B by TRIP6 expression — UCEC

Explore this box plot interactively →