TRIP6

Across TCGA pan-cancer cohorts, TRIP6 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRIP6 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TRIP6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRIP6 expression acts as an unfavorable survival marker, although some lineages such as KIRP and STAD show a favorable association.

COAD, KIRP, and LGG are the cancer types where TRIP6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.742	0.861	<.001	69	view →
KIRP	DFS	Median	III,IV	0.801	0.140	.002	55	view →
LGG	DFS	Median	All	0.276	0.481	<.001	53	view →
LAML	DFS	Tertile	All	0.418	0.691	.001	36	view →
OV	OS	Median	II,III,IV	0.280	0.370	.010	32	view →
PAAD	DFS	Quartile	All	0.183	0.467	.002	26	view →
STAD	OS	Quartile	III,IV	0.607	0.298	.002	20	view →
UCS	OS	Quartile	III,IV	0.151	0.523	.028	18	view →
TGCT	DFS	Median	All	0.735	0.928	.001	18	view →
LIHC	OS	Tertile	All	0.727	0.864	.010	14	view →
HNSC	DFS	Tertile	All	0.690	0.786	.025	11	view →
CHOL	DFS	Tertile	All	0.482	0.115	.026	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRIP6–COAD (OS)

Open the COAD breakdown →