TRIP6

Across TCGA cell cohorts, TRIP6 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIP6-associated genes across cancer lineages are ETNPPL, DEFA4, and ELOA3DP. Each is linked with TRIP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIP6-to-partner and partner-to-TRIP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETNPPL grouped by TRIP6-low versus TRIP6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP6→partner) and Y-score (partner→TRIP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETNPPL →	+0.198	+3.758	.006	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ELOA3DP →	+0.036	+3.688	<.001	.002	3	1
LARGE_INTESTINE	BPIFA1 →	+0.134	+3.688	.001	.002	3	1
SKIN	OR5B17 →	+0.019	+4.415	<.001	.007	3	1
SKIN	PRODH2 →	+0.037	+4.095	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ETNPPL by TRIP6 expression — LARGE_INTESTINE

Explore this box plot interactively →