TRIP12

Across TCGA patient cohorts, TRIP12 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIP12-associated genes across cancer lineages are Caspase-7-cleavedD198, Gab2, and p70-S6K_pT389. Each is linked with TRIP12 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIP12-to-partner and partner-to-TRIP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TRIP12-low versus TRIP12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP12→partner) and Y-score (partner→TRIP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.436	+1.145	.004	.019	3	4
UCEC	Gab2 →	+0.195	+0.956	.034	.023	3	3
UCEC	p70-S6K_pT389 →	-0.120	-1.152	.013	.044	3	3
UCEC	PCNA →	+0.171	+1.807	.002	.003	3	3
UCEC	ASNS →	+0.326	+1.087	<.001	.010	3	3
UCEC	Cyclin-B1 →	+0.460	+1.874	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Caspase-7-cleavedD198 by TRIP12 expression — UCEC

Explore this box plot interactively →