TRIOBP

Across TCGA cell cohorts, TRIOBP mutation is significantly associated with the RNA expression of many other genes, with 1,143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIOBP-associated genes across cancer lineages are OR9G1, RAX, and MSH4. Each is linked with TRIOBP in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIOBP-to-partner and partner-to-TRIOBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9G1 grouped by TRIOBP-low versus TRIOBP-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIOBP→partner) and Y-score (partner→TRIOBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR9G1 →	+0.010	+3.781	<.001	.009	3	3
CNS	RAX →	+0.183	+2.321	.002	.009	3	3
LARGE_INTESTINE	MSH4 →	+0.330	+2.564	<.001	<.001	2	4
BLOOD_Myeloma	KIAA2012 →	+0.006	+3.716	<.001	.005	3	2
OVARY	HTR5A →	+0.124	+3.990	<.001	.003	3	2
CNS	LACTBL1 →	+0.285	+2.874	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,143 associations by consensus.

OR9G1 by TRIOBP expression — BREAST

Explore this box plot interactively →