TRIML2

Across TCGA patient cohorts, TRIML2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIML2-associated genes across cancer lineages are Bim, PCNA, and Rab11. Each is linked with TRIML2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIML2-to-partner and partner-to-TRIML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bim grouped by TRIML2-low versus TRIML2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIML2→partner) and Y-score (partner→TRIML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Bim →	+0.316	+3.000	.039	.036	3	2
UCEC	PCNA →	+0.178	+2.321	.012	.033	3	2
UCEC	Rab11 →	-0.097	-1.392	.041	.019	3	2
UCEC	Caspase-8 →	-0.225	-2.558	.006	<.001	3	2
UCEC	Cyclin-B1 →	+0.514	+2.459	.005	.018	3	2
UCEC	Di-Ras3 →	-0.157	-1.938	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Bim by TRIML2 expression — LUAD

Explore this box plot interactively →