TRIML1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TRIML1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRIML1-associated genes across cancer lineages are Akt_pT308, PREX1, and Smad4. Each is linked with TRIML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIML1-to-partner and partner-to-TRIML1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIML1→partner) and Y-score (partner→TRIML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMAkt_pT308 →-0.360-1.321.031.02832
SKCMPREX1 →-0.252-2.087.021.00432
SKCMSmad4 →+0.092+1.734.014.02132
UCECCaspase-8 →-0.200-2.673.017.00532
UCEC14-3-3_beta →-0.080-3.432.018.00532
UCECMEK1 →+0.416+3.807<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration