TRIM9

Across TCGA patient cohorts, TRIM9 mutation is significantly associated with the RNA expression of many other genes, with 3,204 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM9-associated genes across cancer lineages are ECHS1, B3GNT4, and PAPLN. Each is linked with TRIM9 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM9-to-partner and partner-to-TRIM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECHS1 grouped by TRIM9-low versus TRIM9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM9→partner) and Y-score (partner→TRIM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ECHS1 →	+0.307	+1.771	.001	<.001	3	4
COAD	B3GNT4 →	+0.504	+2.834	<.001	.001	3	4
COAD	PAPLN →	-0.590	-3.670	.003	.001	3	3
UCEC	XPNPEP1 →	+0.311	+1.584	.002	<.001	3	3
UCEC	MRPS27 →	+0.322	+1.385	.003	.009	3	3
UCEC	BNIP1 →	+0.264	+2.445	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,204 associations by consensus.

ECHS1 by TRIM9 expression — UCEC

Explore this box plot interactively →